余    刚 职       称：长聘教轨副教授，PI，博士生导师 所属学科：植物科学系（植物病理学） 研究方向：植物与土传病害分子互作 电子信箱：gangyu@sjtu.edu.cn

 

个人简历：

2022.6-至今 威斯尼斯人wns579，课题组长，博士生导师

2016-2022 中科院分子植物科学卓越创新中心 (上海植物逆境中心)，博士后

2013-2015 美国加州大学戴维斯分校 (UC Davis)，植物病理系，联合培养博士

2010-2016 吉林大学，植物科学学院，植物学博士

2006-2010 吉林大学，植物科学学院，植物保护本科

ORCID: https://orcid.org/0000-0002-6720-7490

 

主要研究内容：

课题组围绕“植物抵御土传病害侵染”这一核心问题展开工作，长期致力于植物与土传病害（青枯菌）分子互作研究，前期发现青枯菌通过分泌三型效应因子（T3E），抑制植物抗病反应，操纵植物代谢，从而壮大病菌种群，最终使植物发病。

课题组现以茄科作物与青枯菌分子互作为研究模式，从茄科作物与病原细菌两个方面开展工作，核心回答茄科作物抗病机制解析及挖掘利用抗病基因这个重要问题。主要包括：

(1) 细胞壁主动参与抗病反应分子机制。

(2) 效应子蛋白操纵植物免疫及发育分子机制。

(3) 新型抗病受体蛋白挖掘及应用。

 

主要承担项目：

(1)  纤维素合成相关蛋白CSI1介导的植物细胞壁免疫机制研究，国家自然科学基金面上项目，2023.1-2026.12，主持；

(2)  植物根系对病原细菌的天然免疫分子机制解析，国家自然科学基金面上项目，2022.1-2024.12，主要参与人 (2/5)；

(3)  植物性状形成的环境塑造机制(病原体侵染与植物营养代谢相互作用的机制研究)，中国科学院战略性先导科技专项(B类)，2018-2023，主要参与人 (2/4)；

(4) 番茄青枯病菌效应子蛋白Rip32生化与生物学功能解析，中国博士后基金一等资助，2016.11-2018.11，主持。

 

主要研究论文(^#为一作，^*为通讯)

(12) Gang Yu^#, Maria Derkacheva^#,*, Jose S. Rufian^#, Carla Brillada, Kathrin Kowarschik, Shushu Jiang, Paul Derbyshire, Miaomiao Ma, Thomas A. DeFalco, Rafael J. L. Morcillo, Lena Stransfeld, Yali Wei, Jian-Min Zhou, Frank L.H. Menke, Marco Trujillo, Cyril Zipfel^*, and Alberto P. Macho^*. The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector. The EMBO Journal, 2022, 41(23): e107257.

(11) Suhui Lv^#, Yu Yang^#, Gang Yu^#, Li Peng, Shuai Zheng, Sunil Kumar Singh, Juan Ignacio       Vílchez, Richa Kaushal, Hailing Zi, Dian Yi, Yuhua Wang, Shaofan Luo, Xiaoxuan Wu, Ziwei Zuo, Weichang Huang, Renyi Liu, Jiamu Du, Alberto P Macho, Kai Tang, Huiming Zhang^*. Dysfunction of histone demethylase IBM1 in Arabidopsis causes autoimmunity and reshapes the root microbiome. The ISME Journal, 2022, 16: 2513-2524.

(10) Hao Xue^#, Gang Yu^#, Lu Zhang, Meng Li, Rosa Lozano-Duran^*, and Alberto P. Macho^*. Ralstonia solanacearum alters root developmental programs in auxin-dependent and independent manners. 2022, bioRxiv, doi: 10.1101/2022.06.22.497157.

(9) Liping Wang^#*, Gang Yu^#*, Alberto P. Macho, and Rosa Lozano-Duran. Split-luciferase complementation imaging assay to study protein-protein interactions in Nicotiana benthamiana. Bio-protocol, 2021, 11(23): e4237.

(8) Gang Yu^*, Liu Xian, Haiyan Zhuang and Alberto Macho^*. SGT1 is not required for plant LRR-RLK-mediated immunity. Molecular Plant Pathology, 2021, 22: 145-150.

(7) Gang Yu, Liu Xian, Hao Xue, Wenjia Yu, Jose Rufian, Yuying Sang, Rafael Morcillo, Yaru Wang, and Alberto P. Macho^*. A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity. PLoS Pathogens, 2020, 16(9):e1008933.

(6) Liu Xian^#, Gang Yu^#, Yali Wei, Yansha Li, Hao Xue, Rafael J. L. Morcillo, Jose S. Rufian, and Alberto P. Macho^*. A bacterial effector protein hijacks plant metabolism to support bacterial nutrition. Cell Host & Microbe, 2020, 28(4): 548-557.

(5) Gang Yu, Liu Xian, Yuying Sang, Alberto P. Macho^*. Cautionary notes on the use of Agrobacterium-mediated transient gene expression upon SGT1 silencing in Nicotiana benthamiana. New Phytologist, 2019, 222: 14-17.

(4) Ling Liu, Qiaochu Wang, Ying Sun, Yanhua Zhang, Xianghui Zhang, Jinliang Liu, Gang Yu^*, and Hongyu Pan^*. Sssfh1, a gene encoding a putative component of the RSC chromatin remodeling complex, is involved in hyphal growth, reactive oxygen species accumulation, and pathogenicity in Sclerotinia sclerotiorum. Frontiers in Microbiology, 2018, 9: 1828.

(3) Xinhua Sun, Gang Yu^*, Jingtao Li, Jinliang Liu, Xueliang Wang, Genglin Zhu, Xianghui Zhang, and Hongyu Pan^*. AcERF2, an ethylene-responsive factor of Atriplex canescens, positively modulates osmotic and disease resistance in Arabidopsis thaliana. Plant Science, 2018, 274: 32-43.

(2) Gang Yu, Jingtao Li, Xinhua Sun, Yanzhi Liu, Xueliang Wang, Hao Zhang, and Hongyu Pan^*. Characterization of salinity tolerance genes expressed in salt-treated Atriplex canescens, IJMS, 2017, 18(11), 2444.

(1) Jingtao Li^#, Gang Yu^#, Xinhua Sun, Yanzhi Liu, Jinliang Liu, Xianghui Zhang, Chengguo Jia, Hongyu Pan^*. AcPIP2, a plasma membrane intrinsic protein from halophyte Atriplex canescens, enhances plant growth rate and abiotic stress tolerance when overexpressed in Arabidopsis thaliana, Plant Cell Reports, 2015, 24(8): 1401-1415.

 

学术期刊发表的非第一作者论文

(11) Choghag Demirjian^#, Narjes Razavi^#, Gang Yu, Baptiste Mayjonade, Lu Zhang, Fabien  Lonjon, Fabien Chardon, Sébastien Carrere, Jérome Gouzy, Stéphane Genin, Alberto P.  Macho, Fabrice Roux, Richard Berthomé, Fabienne Vailleau. An atypical NLR gene confers bacterial wilt susceptibility in Arabidopsis. Plant Communications, 2023, DOI:  https://doi.org/10.1016/j.xplc.2023.100607.

(10) Jingtao Li, Xiaoying Ma, Chenyang Wang, Sihui Liu, Gang Yu, Mingming Gao, Hengwei Qian, Mengjie Liu, Ben F Luisi, Dean W Gabriel, Wenxing Liang^*. Acetylation of a fungal effector that translocates host PR1 facilitates virulence. eLife, 2022, 11: e82628.

(9) Julian Dindas^#, Thomas A. DeFalco^#, Gang Yu, Lu Zhang, Pascale David, Marta Bjornson, Marie-Christine Thibaud, Valéria Custódio, Gabriel Castrillo, Laurent Nussaume, Alberto P. Macho, and Cyril Zipfel^*. Direct inhibition of phosphate transport by plant immune signaling. Current Biology, 2022, 32 (2), 488-495.

(8) Yanru Wang^#, Liu Xian^#, Gang Yu, and Alberto P. Macho^*. Tomato stem injection for the precise assessment of Ralstonia solanacearum fitness in planta. Bio-protocol, 2021, 11(16): e4134.

(7) Liu Xian, Gang Yu, and Alberto P. Macho^*. The GABA transaminase GabT is required for full virulence of Ralstonia solanacearum in tomato. microPublication Biology, 2021, DOI: 10.17912/micropub.biology.000478.

(6) Liping Wang^#,*, Gang Yu^#,*, Alberto P. Macho, Rosa Lozano-Duran. Split-luciferase complementation imaging assay to study protein-protein interactions in Nicotiana benthamiana. Bio-protocol, 2021,11(23):e4237.

(5) Yaru Wang, Rafael Morcillo, Achen Zhao, Gang Yu, Hao Xue, Jose S. Rufian, Yuying Sang, and Alberto P. Macho^*. A bacterial effector uncovers a metabolic pathway involved in resistance to bacterial wilt disease. Molecular Plant, 2021, 14(8):1281-1296.

(4) Yuying Sang^#, Wenjia Yu^#, Haiyan Zhuang, Yali Wei, Lida Derevnina, Gang Yu, Jiamin Luo, Alberto P. Macho^*. Intra-strain elicitation and suppression of plant immunity by Ralstonia solanacearum type-III effectors in Nicotiana benthamiana. Plant Communications, 2020: 10.1016/j.xplc.2020.100025.

(3) Huidong Fan, Gang Yu, Yanzhi Liu, Xianghui Zhang, Jinliang Liu, Yanhua Zhang, Jeffery A. Rollins, Fengjie Sun, and Hongyu Pan^*. An atypical forkhead containing transcription factor SsFkh1 is involved in sclerotial formation and is essential for pathogenicity in Sclerotinia sclerotiorum, Molecular Plant Pathology, 2017, 18(7):963-975.

(2) Jingtao Li, Gang Yu, Xinhua Sun, Xianghui Zhang, Jinliang Liu and Hongyu Pan^*. AcEBP1, an ErbB3-Binding Protein (EBP1) from halophyte Atriplex canescens, negatively regulates cell growth and stress responses in Arabidopsis, Plant Science, 2016, 248: 64-74.

(1) DongHyuk Lee, Gildas Bourdais, Gang Yu, Silke Robatzek, and Gitta Coaker^*. RIN4 phosphorylation enhances plant plasma membrane H⁺-ATPase activity and inhibits flagellin-triggered immune responses. The Plant Cell, 2015, 27 (7):2042-2056.

 

招生和招聘

欢迎对本课题组研究方向感兴趣的优秀博士生应聘博士后和专职科研岗；

欢迎有植物病理学、遗传学和生物化学背景的学生报考本实验室硕士、博士研究生及推免硕博生；

欢迎本科生到本课题组做实验实习，参与科研项目，毕业设计。